Research indicates that GLP-1 medications could offer health benefits that go beyond merely aiding weight loss. According to increasing studies, these drugs might also lower cardiovascular risks and help with joint pain and inflammation.
Here are seven potential advantages that extend beyond just losing weight.
No. 1: Protecting heart health
Studies suggest that semaglutide—the active component in drugs like Ozempic and Wegovy—may provide cardiovascular benefits that aren’t solely linked to weight loss. One notable study in The Lancet revealed that semaglutide significantly reduced the chances of heart attacks, strokes, and cardiovascular-related deaths in individuals with pre-existing cardiovascular conditions who were overweight or obese. Interestingly, these benefits appeared across various body weights and were not completely attributable to weight loss.
No. 2: Reducing joint pain and improving mobility
There’s been a correlation between GLP-1 medications and decreased joint pain, though it’s still unclear how much of this is due to weight loss as opposed to other effects. For instance, in the STEP 9 clinical trial published in the New England Journal of Medicine, semaglutide significantly mitigated knee osteoarthritis pain and enhanced physical function among obese adults.
No. 3: Promoting kidney health
GLP-1 medications might help safeguard kidney function through various mechanisms, such as bettering blood sugar levels, blood pressure, and inflammation. The landmark FLOW trial published in the New England Journal of Medicine found that semaglutide lowered the risk of serious kidney issues and cardiovascular mortality by 24% among patients with type 2 diabetes and chronic kidney disease.
No. 4: Reducing liver inflammation and scarring
MASH, or metabolic dysfunction-associated steatohepatitis, is a serious variant of fatty liver disease characterized by inflammation and liver cell damage. Research suggests that GLP-1 medications can positively impact liver health, although it’s uncertain how much of this is independent of weight loss. A clinical trial recently noted that semaglutide led to improvements in liver tissue among patients with MASH, including decreased inflammation and liver scarring, with 62.9% of those receiving the medication showing resolution of MASH.
No. 5: Reducing respiratory flare-ups
Recent studies presented at the European Respiratory Society Congress suggest that GLP-1 medications may contribute to fewer asthma attacks and flare-ups in COPD. The belief is that the anti-inflammatory properties of the drugs could play a role, although more research is necessary to explicitly link these medications to enhanced respiratory health.
No. 6: Supporting mental health and curbing addiction
The brain has GLP-1 receptors in areas tied to appetite regulation, emotions, motivation, and reward responses. Emerging studies hint at the potential mental health benefits of semaglutide and even its effects on addiction. One observational study found a connection between semaglutide use and lower rates of substance-related and mood disorders, but it’s essential to note that these findings are preliminary and not yet peer-reviewed, leaving some uncertainty about causation.
No. 7: Soothing severe skin conditions
GLP-1 medications are also under examination for their ability to help with inflammatory skin issues, such as psoriasis. A clinical trial published in JAMA Dermatology found that adding tirzepatide to ongoing psoriasis treatment improved skin clearance for those with moderate to severe cases who were also overweight. Researchers continue to assess whether these improvements stem from weight loss, reduced inflammation, or a mix of factors.
It’s important to remember that the effects of GLP-1 medications can differ depending on the specific drug and individual. Thus, consulting a healthcare provider about the related risks and benefits is advisable.
