A dietitian has discussed some surprising supplements that could enhance the effects of popular weight loss medications.
With around 30 million adults in the U.S. using medications like Ozempic and Wegovy, these injections have significantly transformed the weight loss landscape and diabetes management.
These drugs function by imitating glucagon-like peptide-1 (GLP-1), a hormone found naturally in the gut which helps slow down digestion, manage blood sugar, and signal fullness. This mechanism can be quite beneficial in controlling both diabetes and weight.
However, because GLP-1 medications slow down gastric emptying, individuals using them might need to modify their eating habits and supplement routines to dodge pesky side effects like nausea, constipation, and bloating.
In her recent book, Your Best Shot: The Personalized System for Optimal Weight Health – GLP-1 Shot or Not, California-based dietitian Ashley Koff shares valuable insights about these weight loss injections.
In an interview, Koff, who has been a dietitian for over 25 years, pointed out certain supplements that research suggests could amplify the effects of these medications.
She emphasized that while well-known supplements like omega-3s and fiber contribute to better digestion and a feeling of fullness, other lesser-known options such as berberine and Amarasate might boost the body’s production of GLP-1.
Still, she warned that no supplement can replace these medications for those who need them due to health conditions.
“There’s a lot of misinformation about supplements,” Koff mentioned. “There is no ‘nature’s Ozempic’—no supplement can mimic the medications, which work around the clock.”
She acknowledged that some supplements can help increase GLP-1 levels, but they don’t come close to the efficacy of the medications.
Berberine
Berberine is a plant-based compound found in herbs like barberry and Oregon grape. Traditionally used for various health issues, it’s now available as a supplement for blood sugar, cholesterol, and weight management.
Prices for berberine range from $10 to $50 per bottle, and since it has a bitter flavor, it stimulates taste receptors that encourage the release of GLP-1, enhancing the effects of weight loss medications.
“By activating bitter taste receptors, it can support our body’s hormonal balance,” Koff stated. However, she noted that it may interact with medications for blood pressure or cholesterol, so caution is advised for those on these treatments.
Probiotics
Probiotics, which are beneficial bacteria found in the gut and in fermented foods like kimchi and kefir, play an important role in digestion and nutrient absorption.
Koff highlighted Akkermansia muciniphila, a particular probiotic that has been shown to improve gut barrier function and reduce inflammation.
“Muciniphilia thrives on mucin, breaking down the mucosal layer,” she explained, adding that this process may help stimulate GLP-1 production as a result.
While Akkermansia muciniphila isn’t consumed directly, its growth in the gut can be encouraged through foods high in polyphenols, like berries and dark chocolate. It’s also available as a supplement, costing between $20 and $80 depending on the brand.
Glutamine
Koff recommended glutamine, an amino acid prevalent in the body. It’s found in various foods such as meats, dairy, and legumes, and is available as a supplement that ranges from $10 to $40.
Glutamine, in either food or supplement form, aids in the release of GLP-1 and has been noted for strengthening the intestinal lining, which can help minimize inflammation that could disrupt GLP-1 signaling.
Amarasate
Amarasate, derived from New Zealand hops, is another natural extract similar to berberine. Marketed as an appetite control aid, this supplement costs between $70 and $90 for a bottle of 90 capsules.
Like berberine, it stimulates bitter taste receptors that boost GLP-1 release and can induce feelings of fullness. Koff mentioned that Amarasate could be particularly beneficial for people transitioning off GLP-1 medications like Ozempic, as it encourages hormone production with few side effects.
Interestingly, it can curb hunger in just about 30 minutes, which is quite impressive.
