Drugs that may extend lifespan large dog It is nearing U.S. Food and Drug Administration (FDA) approval.
This is according to last week's announcement. San Francisco Royal, the biotechnology company that developed the drug.
Currently, there are no FDA-approved or conditionally approved veterinary drugs for this purpose.
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“There are 25 million large dogs in the United States alone, and it's these 25 million dogs that we can help live longer and improve the quality of our lives,” said Loyal Founder and CEO. Celine Harioua said in a statement to Fox News Digital. .
The company claims a drug called LOY-001 may help slow down aging process For dogs over 40 pounds.
This drug works by interacting with a hormone called IGF-1, which accelerates the aging process. A Royal spokesperson said the drug is designed to prevent age-related illnesses in dogs, rather than waiting until symptoms appear.
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“Royal's approach represents a different paradigm that uses our understanding of the mechanisms underlying aging to reduce the risk of these diseases in the first place,” the company said in a release sent to Fox News Digital. Ta.
Last week, the drug company announced that LOY-001 had cleared initial hurdles with the FDA, suggesting that data so far indicates the drug's potential efficacy.
However, many more milestones must be achieved before the drug is fully approved and brought to market.
These include completing large-scale projects. clinical trial and review of safety and manufacturing data.
According to Royal's website, the four-year process includes an FDA-approved intervention study of LOY-001 in a canine aging model and an observational (non-drug) study of 451 dogs. include.
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“Today's milestone is an important part of Royal's application for conditional approval,” the company said in a news release.
“This means that the FDA agrees that LOY-001 has a reasonable expectation of efficacy,” the statement continued. “If the FDA approves Royal's manufacturing and safety data package, Royal will be able to market this drug for the purpose of extending the lives of eligible dogs.”
“The conditional approval will last for up to five years, during which time Royal will collect remaining efficacy data and apply for full approval.”
According to veterinarians who spoke to Fox News Digital, the average lifespan of a dog is about 10 to 13 years, with larger dogs aging faster and having shorter lifespans.
Body size and growth rate are important factors that affect a dog's lifespan.
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Dr. Ivana Kurnek (veterinarian) Texas based The Veterinarians.org Foundation told FOX News Digital that body size and growth rate are important factors that influence a dog's lifespan.
The growth-promoting hormone IGF-1, which is thought to play a role in accelerating aging and shortening lifespan, has been detected at much higher levels in large dogs compared to small dogs.
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“In my professional opinion, this drug is a breakthrough,” Kruneck said.
“We still have to wait and see about its results and potential side effects, but so far LOY-001 is definitely promising,” she continued. “The fact that the FDA said there was a 'reasonable expectation of efficacy' for this drug says a lot about its potential.” (She was not involved in that study.)
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The drug “indirectly has a positive impact on quality of life in large and giant dog breeds” by slowing the effects of aging on important functions, Kruneck told Fox News Digital. .
“We still have to wait and see the results and potential side effects, but for now LOY-001 is definitely promising.”
Other veterinarians said they were cautiously optimistic.
“It seems too good to be true,” said Dr. Jeffrey Krasnoff, a veterinarian at Brookville Animal Hospital. long islandcommented on Fox News Digital about experimental drugs.
“I would love to see the research. It would be great if it really made a difference in the lifespan of our large breed dogs.”
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Royal's website says the drug is administered by veterinarian injection every three to six months, but the company is working on a daily pill.
LOY-001 is expected to be launched in 2026, subject to FDA approval of Royal's manufacturing and safety data.
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