Researchers from the University of Southern Denmark, analyzing data from Danish twin pairs, have found evidence suggesting that tattoo ink may elevate the risk of skin and lymphoma cancers. This potential risk is linked to the accumulation of tattoo ink in the lymph nodes. These findings highlight concerns about the long-term health effects of tattooing.
Many people carefully consider their choice of tattoo, but one aspect often overlooked is its potential long-term impact on health. What happens to the ink once it’s injected into the skin? Does it stay in place, or does it move elsewhere in the body?
Research indicates that tattoo ink doesn’t remain confined to the skin. Instead, ink particles can migrate to the lymph nodes, where they accumulate over time.
A collaborative study by researchers from the University of Southern Denmark’s Department of Public Health and Department of Clinical Research, along with the University of Helsinki, examined the possible health effects of this ink migration. Using data from Danish twin pairs, they found that individuals with tattoos were more frequently diagnosed with skin cancer and lymphoma compared to those without tattoos.
Ink particles in the body may affect the immune system
The lymph nodes are a crucial part of the immune system, helping to fight infections and filter harmful substances from the body.
When tattoo ink penetrates the skin, some of it is absorbed into the lymph nodes. The researchers are particularly concerned that tattoo ink may trigger chronic inflammation in the lymph nodes, which over time could lead to abnormal cell growth and an increased risk of cancer.
“We can see that ink particles accumulate in the lymph nodes, and we suspect that the body perceives them as foreign substances,” explains Henrik Frederiksen, consultant in hematology at Odense University Hospital and clinical professor at SDU.
“This may mean that the immune system is constantly trying to respond to the ink, and we do not yet know whether this persistent strain could weaken the function of the lymph nodes or have other health consequences.”
Studying this link is challenging because cancer can take years to develop. This means that exposure in youth may not lead to illness until decades later, making it difficult to measure a direct effect.
Twin data provides a unique opportunity to study the link
The study is based on data from the Danish Twin Tattoo Cohort, where researchers have information from more than 5,900 Danish twins. By analyzing tattoo patterns alongside cancer diagnoses, they found a higher occurrence of both skin and lymphoma cancers in tattooed individuals.
“The unique aspect of our approach is that we can compare twin pairs where one has cancer, but they otherwise share many genetic and environmental factors,” says Jacob von Bornemann Hjelmborg, professor of biostatistics at SDU.
“This provides us with a stronger method for investigating whether tattoos themselves may influence cancer risk.”
The size of tattoos matters
The results show that the link between tattoos and cancer is most evident in those with large tattoos – defined as bigger than a palm.
For lymphoma, the rate is nearly three times higher for the group of individuals with large tattoos compared to those without tattoos. This rate (more specifically, ‘hazard rate’) accounts for age, the timing of the tattoo, and how long the individuals have been followed in the study.
“This suggests that the bigger the tattoo and the longer it has been there, the more ink accumulates in the lymph nodes. The extent of the impact on the immune system should be further investigated so that we can better understand the mechanisms at play,” says Signe Bedsted Clemmensen, assistant professor of biostatistics at SDU.
Another study from the Danish Twin Tattoo Cohort shows that tattoos are becoming increasingly common. Researchers estimate that four in ten women and three in ten men will have tattoos by the age of 25.
The link to lymphoma has also been observed in an independent Swedish study from 2024.
Are some ink colors worse than others?
Previous research has suggested that certain pigments in tattoo ink may be more problematic than others.
“In our study, we do not see a clear link between cancer occurrence and specific ink colors, but this does not mean that color is irrelevant. We know from other studies that ink can contain potentially harmful substances, and for example, red ink more often causes allergic reactions. This is an area we would like to explore further,” says Signe Bedsted Clemmensen.
What are the next steps?
The researchers now plan to investigate how ink particles affect the function of lymph nodes at a molecular level and whether certain types of lymphoma are more linked to tattoos than others.
“We want to gain a better understanding of the biological mechanisms—what happens in the lymph nodes when they are exposed to ink particles over decades? This can help us assess whether there is a real health risk and what we might do to reduce it,” concludes Signe Bedsted Clemmensen.
The Danish Twin Tattoo Cohort
- Established to investigate the link between tattoos and cancer.
- Based on survey responses from 5,900 Danish twins.
- Examines both tattooing behavior and the occurrence of skin and lymphoma cancers among tattooed individuals.
- Unique method: By comparing twins, researchers can separate genetic factors from environmental influences.
- It is linked to the Danish Cancer Registry to analyze cancer occurrence among participants.
How many Danes have tattoos?
- According to the Danish Environmental Protection Agency (2017), approximately 600,000 Danes have a tattoo—equivalent to about 14% of the population.
- A 2021 study shows that 30-40% of Danes under the age of 35 have a tattoo.
- Researchers from the Danish Twin Tattoo Cohort estimate that four in ten women and three in ten men will have tattoos by the age of 25.
- On a global scale, tattoos have become increasingly popular over the past 30 years, especially among young people and women.
Reference: “Tattoo ink exposure is associated with lymphoma and skin cancers – a Danish study of twins” by Signe Bedsted Clemmensen, Jonas Mengel-From, Jaakko Kaprio, Henrik Frederiksen and Jacob von Bornemann Hjelmborg, 15 January 2025, BMC Public Health.
DOI: 10.1186/s12889-025-21413-3
