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Nikki Glaser mocks Diddy, Ben Affleck in Golden Globes monologue

Golden Globe Awards, tune in – Nikki Glazer will host.

Glazer, 40, opened the show with a tribute to weight loss pills and declared today to be “Ozempic's biggest night.”

Glazer, who took to the stage live from the Beverly Hilton Hotel in Beverly Hills, Calif., praised Zendaya's role in Challengers, a movie about a tennis ace who finds herself in a love triangle with her husband and ex-girlfriend.

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Comedian Nicky Glazer joked about Diddy and Ben Affleck in his opening monologue at the Golden Globes. (Rich Pork)

“That movie was more sexual than Diddy's Credit Card,” Glazer said. “I know…I'm upset too. The after-party isn't so great.”

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She joked that Stanley Tucci would have to host from now on. “There's no baby oil this year, just olive oil,” Glaser said.

On March 25, Sean “Diddy” Combs' homes in Los Angeles and Miami were searched in connection with a federal human trafficking investigation, officials confirmed to FOX News Digital at the time.

Nikki Glazer in a brown dress at the 2025 Golden Globe Awards.

Nikki Glazer walked the red carpet before hosting the 82nd Annual Golden Globe Awards at the Beverly Hilton Hotel. (Jordan Strauss/Invision/Associated Press)

Sean Diddy Combs is wearing a white cardigan

Sean “Diddy” Combs was charged in an indictment unsealed in September with racketeering conspiracy, sex trafficking by force, fraud and coercion, and transportation to engage in prostitution. (Munawar Hossain)

During the search, authorities allegedly seized various “freak-off” materials, including drugs and more than 1,000 bottles of baby oil and lube, according to a federal indictment.

As the nominees continued to be announced, top stars were also thrown into Glazer's mix.

“'Evil', 'queer', 'night bitch'…these aren't just words Ben Affleck screams during orgasm,” Glazer said.

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Ben Affleck and Jennifer Lopez at the 81st Golden Globe Awards Ceremony

Jennifer Lopez filed for divorce from Ben Affleck in August after two years of marriage. (Christopher Polk)

Affleck is in divorce talks with his second wife, Jennifer Lopez.

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Before the show, Glaser reflected on his 22 years of hard work in the industry to get to where he is today.

“I started doing 'Last Comic Standing' when I was in college,” Glaser told CBS, before going on to elaborate on the show on MTV and Comedy Central.

Comedian Nikki Glazer takes the microphone on stage at the Golden Globe Awards.

Glazer also took a jab at Ben Affleck. (Rich Pork)

One person who gave her important advice about hosting was former Golden Globes host Ricky Gervais.

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“You're going to do well,” she recalled Mr. Gervais saying. “You're not one of them.”

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