Let’s face it: Most people probably don’t think to check their skin for signs of heart disease risk. It seems unrelated, right? But that’s not entirely true, according to experts. “Your skin is the largest organ in your body, and it often reflects your overall health,” notes Dr. Karuppiah “Kar” Arunachalam, MD, a cardiovascular disease specialist at the Orlando Heart Health and Vascular Institute.
He, along with a dermatologist, discusses how a specific change in skin might be linked to heart concerns.
This Surprising Skin Change May Signal Heart Disease
One connection between skin health and heart health is something called “xanthomas.” These are yellowish to orangish bumps on the skin that can indicate high cholesterol—a significant risk factor for heart disease.
Indeed, cholesterol levels are crucial when talking about heart health. A simple blood test is becoming increasingly recognized as an important measure of risk.
“Elevated cholesterol, particularly LDL (the bad kind), can lead to a buildup of plaque in the arteries, a process known as atherosclerosis,” explains Dr. Angela Moore, MD, a dermatologist and associate professor at TCU. “This buildup narrows arteries and limits blood flow, heightening the risks for heart attacks and strokes.”
But about xanthomas again: “They are often linked to familial hyperlipidemia, a genetic condition tied to elevated cholesterol levels,” Dr. Arunachalam notes. “People with this condition are at risk for serious issues like coronary artery disease, stroke, and persistent ulcers.”
Xanthomas come in various forms. The most common type, xanthelasma, appears mostly around the eyelids and can be benign or indicative of high cholesterol. Other varieties can show up on different body parts like elbows, palms, or tendons, depending on the type.
If you’re unsure what you’re dealing with, a biopsy can help differentiate skin lesions, though a skilled clinician can typically spot them right away.
If high cholesterol is diagnosed, addressing it can potentially prevent new xanthomas and may even diminish existing ones, according to Dr. Moore.
To lower cholesterol, options include about 150 minutes of moderate exercise each week and incorporating cholesterol-lowering foods like oats, salmon, and dark chocolate into your diet.
Other Skin Changes That May Be Linked to Heart Disease
It’s crucial to recognize that xanthomas aren’t the only skin changes that might indicate heart problems. Here are a few more signs to watch out for:
- Bluish discoloration of the fingertips can be indicative of cyanotic heart disease in children.
- Creases in the earlobe may hint at atherosclerotic heart disease.
- Red spots on the palms and fingers could be linked to infections affecting heart valves.
- Poorly managed skin conditions like psoriasis may contribute to inflammation that exacerbates atherosclerosis.
- Swelling in the lower legs, known as stasis dermatitis, can also be a risk factor for heart disease.
Dr. Arunachalam stresses the importance of seeking medical advice if you notice any skin changes. “Identifying these issues early can help prevent complications related to high cholesterol,” he says.
Dr. Moore concurs, advising that if you have any lingering lesions or swelling, it’s best to consult a doctor or dermatologist to rule out any serious conditions or inflammation.
In summary, skin issues can sometimes signal deeper, life-threatening heart conditions.
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This story was originally reported by Parade on Sep 4, 2025.
