In Week 5 of the 2025 NFL season, we’ve got an NFC West face-off on Thursday night. The Rams are coming in as 7-point favorites and there’s a 46.5 over/under. Both teams are looking to capitalize on their 3-1 records and keep their positions secure in this fierce division.
Let’s dive into the top DFS picks for this Thursday night clash.
Christian McCaffrey, RB, San Francisco 49ers (Flex $13,200, CPT $19,800)
McCaffrey stands out as a top pick for this game, and there are solid reasons for that. He’s back in form after an injury-plagued season last year and his pass-catching ability is just remarkable—he’s racked up 305 receiving yards, making him the top running back in that category and even ranking 8th among all receivers.
Plus, have you checked out the 49ers’ recent injury woes? With key players like Brock Purdy and Ricky Piersol sidelined, McCaffrey might have to take on a lot of roles in the offense.
Matthew Stafford, QB, Los Angeles Rams (Flex $11,800, CPT $17,700)
Stafford is heating up, especially after his performance against the Colts last Sunday where he completed around 71% of his passes for 375 yards and three touchdowns. Having two All-Pro receivers, Puka Nacua and Davante Adams, definitely helps. That’s a big reason why the Rams are sitting pretty at 3-1 for this primetime matchup. He’s scoring an average of 19.3 fantasy points per game, making him a solid candidate for the captain spot.
Davante Adams, WR, Los Angeles Rams (Flex $9,800, CPT $14,700)
Now, about Adams—he seems to have clued into a better role with the Rams after some tougher years with the Raiders and Jets. He’s been a reliable WR2 for Stafford, scoring touchdowns in three consecutive games leading up to this one. For $14,700, taking a chance on him in a top lineup spot might pay off, as he could easily find the end zone again.
Jaketons, TE, San Francisco 49ers (Flex $6,000, CPT $9,000)
Tong has stepped up for San Francisco since George Kittle went down in Week 1. He’s been decent for fantasy, too, recently catching a touchdown that brought the 49ers close in their loss to the Jaguars last Sunday. With injuries piling up, Tong could be a crucial player that the team leans on.
Blake Corum, RB, Los Angeles Rams (Flex $4,400, CPT $6,600)
Corum is holding down a backup spot behind Kylen Williams this season, handling the ball nine times and logging about 30% of the snaps in the last game. The 49ers’ defense has been average at best against the run. I think Corum could really seize this opportunity to break out in this matchup, so keep him in mind when setting up your lineup.
Kendrick Bourne, WR, San Francisco 49ers (Flex $3,600, CPT $5,400)
Someone’s going to have to catch passes for the 49ers, and Bourne is stepping up to the challenge. He struggled against the Jaguars last week, with just one catch for 17 yards, while dropping three other potential targets. The opportunities might be limited, but he could be a low-cost option worth considering—fingers crossed he can actually make some catches this Thursday.
