The Buffalo Bills and Philadelphia Eagles have dominated the NFL in the initial four weeks of the 2025 season, winning every game they’ve played so far.
As they approach week 5, they’re faced with significant challenges ahead.
The Bills will take on the New England Patriots in a divisional rivalry that could impact playoff standings, especially if quarterbacks Josh Allen and Drake May continue their strong performances. This matchup is set to add drama to an already intriguing Sunday.
The Eagles will be back on home turf, defending their Super Bowl title against the Denver Broncos. Denver enters this game with a formidable defense, having just stifled Jake Browning and the Cincinnati Bengals. While stopping the Eagles’ tush push will likely be on the Broncos’ to-do list, Philadelphia showed last week that they have some clever tricks up their sleeve.
This week, four teams must sit out: the Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers. Additionally, the Minnesota Vikings are set to make history as the first NFL team to play consecutive international games, taking on the Cleveland Browns in London.
Here’s what the schedule looks like.
Thursday, October 2nd, 2025
- San Francisco 49ers @ Los Angeles Rams (8:15pm ET)
Sunday, October 5th, 2025
- Minnesota Vikings @ Cleveland Browns (9:30am ET)
- Las Vegas Raiders @ Indianapolis Colts (1pm ET)
- New York Giants @ New Orleans Saints (1pm ET)
- Dallas Cowboys @ New York Jets (1pm ET)
- Denver Broncos @ Philadelphia Eagles (1pm ET)
Rookie quarterback Dilongabriel will start for the Vikings in London.
- Miami Dolphins @ Carolina Panthers (1pm ET)
- Houston Texans @ Baltimore Ravens (1pm ET)
- Tennessee Titans @ Arizona Cardinals (4:05pm ET)
- Tampa Bay Buccaneers @ Seattle Seahawks (4:05pm ET)
- Detroit Lions @ Cincinnati Bengals (4:25pm ET)
- Washington Commanders @ Los Angeles Chargers (4:25pm ET)
- New England Patriots @ Buffalo Bills (8:20pm ET)
Monday, October 6th, 2025
- Kansas City Chiefs @ Jacksonville Jaguars (8:15pm ET)
