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Rays prospect Xavier Isaac makes his comeback in his first game after brain surgery.

Rays prospect Xavier Isaac makes his comeback in his first game after brain surgery.

Even though the Rays lost 12-3 to the Tigers, there was a particularly touching event on Saturday involving their top prospect, Xavier Isaac.

This was his first game back after undergoing brain surgery last year. In the eighth inning, the 22-year-old managed to hit a single into the right-field seats, which sparked a joyful celebration among his teammates.

“It was fantastic. The atmosphere in the dugout was electric. Everyone was high-fiving and congratulating him,” said Rays manager Kevin Cash during a press briefing. He added, “The results don’t really matter.”

“Whenever he gets positive feedback or some kind of reward for all the hard work he’s done, I hope he can see it as a special moment. I know we all will remember it fondly,” he remarked.

Isaac, who was picked 29th overall by Tampa Bay in the 2022 MLB Draft, had “lifesaving” surgery to remove a brain tumor in July 2025, which kept him off the field as a first baseman for over eight months.

“Honestly, just being back on the field and being the first one was amazing. I hadn’t played defense for the last two years, so it felt really good to be back,” Isaac shared. “And I got the hit. I felt a huge sense of relief.”

Before his surgery, Isaac last played for Double-A Montgomery, a time he has described as “the scariest moment” of his life.

Isaac commented, “The moment I learned about the surgery, I just stopped worrying about baseball altogether.”

Currently, he is in spring training with the Rays as a non-roster invitee, gearing up for his fifth professional season.

While he performed well in both Low-A and High-A during the 2023-24 season, his performance dipped last season, something he acknowledges might be tied to his brain tumor.

“Mentally, I felt absent last year. It was different, something was off and I couldn’t pinpoint what it was,” he reflected, adding that this likely contributed to his struggles.

According to MLB.com, Isaac was ranked as the Rays’ No. 9 prospect in 2025.

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