More and more Americans are suffering from cancer at a younger age.
Journal “Nature” I got it. Last month, it was announced that the number of early-onset cancer cases is expected to increase by about 30% between 2019 and 2030. Furthermore, although colorectal cancer has historically affected older men, it is now the leading cause of cancer death in men under 50 and is now the leading cause of cancer death. ing. The second leading cause of cancer death among young women. Uterine cancer has increased by 2% each year for the past 30 years. It has been reported that early-onset breast cancer increased by nearly 4% annually from 2016 to 2019.
“If it had been a single smoke bomb, our study would have pointed to at least one contributing factor,” said Sonia Kupfer, a gastroenterologist at the University of Chicago. “But apparently that’s not the case. It seems like a combination of many different factors.”
Various possible factors are taken into account. Rising obesity rates; changes in diet and Responding to changes in intestinal bacteria; Lack of sleep; increased alcohol consumption. And vaccines.
the study presented At the American Association for Cancer Research annual meeting in San Diego this past weekend, he suggested that the alarming rise in cancer among young adults in the United States could be the result of “accelerated aging.” .
“We all know that cancer is a disease.Aging disease. But it’s actually spreading to younger generations. Therefore, the ability to apply well-developed concepts of biological aging to younger generations is a completely unexplored area,” said Dr. Ying Cao, associate professor of surgery at Washington University School of Medicine in St. Louis. author of the study, Said CNN.
Chronological age refers to the period of time that an individual has lived. Biological age, also known as physiological age, refers to the condition of a person’s body and genetic material. So people who are younger by age are more likely to vape, eat too much, not get enough sleep, and are genetically more susceptible to various diseases than people who have seen more sunsets. Could be older.
Cancer has long disproportionately affected older people, but Cao and his fellow researchers say cases of early-onset solid tumors are surging among younger Americans. They began to suspect that this phenomenon was the result of increasing biological age, which is characterized by “accelerated aging.”
“Multiple types of cancer are becoming increasingly common among young people in the United States and globally,” said Ruiyi Tian, a WUSM researcher on Cao’s team. Said The American Association for Cancer Research notes the increase in cancer cases among adults under 55, stating, “Understanding the factors driving this increase can improve prevention and early detection of cancer in young and future generations.” That’s going to be the key.”
“Accumulating evidence suggests that younger generations may be aging faster than expected, possibly due to early exposure to a variety of risk factors and environmental insults. “It’s possible,” Tian continued. “However, the impact of accelerated aging on the development of early-onset cancer remains unclear.”
Tian and colleagues examined data from approximately 150,000 people in the UK Biobank database and identified nine biomarkers found in the blood: albumin, alkaline phosphatase, creatinine, C-reactive protein, glucose, mean corpuscular volume, and red blood cell volume. distribution) was used to calculate each individual’s biological age. Width, white blood cell count, lymphocyte percentage.
according to To Cleveland Clinic:
- Albumin is a protein in plasma. Low levels may indicate kidney disease, liver disease, inflammation, or infection. High values may indicate dehydration or severe diarrhea.
- Alkaline phosphatase is an enzyme present throughout the human body. High levels of enzymes indicate possible liver or bone disease.
- Creatinine is a natural chemical used by the body to activate muscles. High creatinine levels usually indicate kidney damage.
- C-reactive protein is released by the liver into the bloodstream in response to inflammation. Elevated levels suggest a serious infection or inflammatory condition.
- Glucose, or sugar, is carried by the blood to all cells of the body for energy. Elevated blood sugar levels tend to indicate diabetes.
- Mean corpuscular volume refers to the average size of a patient’s red blood cells. A low MCV may be a sign of iron deficiency anemia or other blood disorders. Alternatively, a high MCV could mean vitamin B12 deficiency, folate deficiency, liver disease, or bone marrow dysfunction.
- The width of the red blood cell distribution is measured because discrepancies or large fluctuations can signal anemia.
- A white blood cell count is performed to detect hidden infections, immune deficiencies, autoimmune diseases, and other diseases. Both high and low numbers can indicate a potentially serious problem.
In a study supported by the National Institutes of Health, researchers identified individuals whose biological age, as indicated by these biomarkers, is older than their chronological age as having accelerated aging.
According to Tian and colleagues, people born after 1965 were 17% more likely to experience accelerated aging than those born between 1950 and 1954. They further found that “each standard deviation increase in aging acceleration was associated with a 42% increase in aging.” The risk of early-onset lung cancer increases by 22%, and the risk of early-onset gastrointestinal cancer increases by 36%. ”
Tian speculated that certain types of cancer are strongly associated with accelerated aging based on the nature of the tissues affected. For example, the lungs have limited regenerative capacity, making them susceptible to biological aging.
“If our findings are validated, interventions that slow biological aging could provide a new means of cancer prevention, and screening efforts could be tailored to young people who show signs of accelerated aging. This suggests that it may be useful for early detection of cancer,” said Professor Tian.
The American Cancer Society revealed this in its report. Latest annual report Learn more about cancer facts and trends.More than 2 million people are expected to be newly diagnosed with cancer this year. In the last three years, the estimate was he 1.9 million.
ale medicine I got it. Ostensibly, the only age group where overall cancer rates increased from 1995 to 2020 was younger people.
A total of 611,720 people are expected to die from cancer in the United States this year.
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