The rail company advised customers not to travel north of Preston on Tuesday afternoon due to service suspensions caused by Storm Jocelyn.
Avanti West Coast is one of the railway companies warning the public that train travel will no longer be possible in the north of England and large parts of Scotland.
Mr Avanti said the last train from London to Glasgow on Tuesday departed at 3.30pm and was expected to be very busy.
ScotRail has urged passengers to check before traveling as a number of routes, including Edinburgh to Glasgow, are suspended.
From Tuesday evening, LNER services from London to Edinburgh will end in Newcastle, and southbound services that were due to start in Aberdeen earlier in the day will start in Edinburgh instead.
The companies said affected rail services will be suspended until at least midday Wednesday, and passengers with tickets who were unable to travel will receive a full refund.
Jocelyn is set to bring further wind and rain, a day after Storm Isha left at least two people dead and one seriously injured in the UK. The UK and Ireland are experiencing their most active storm season since record-keeping began.
Isha left hundreds of thousands of homes without power, sparking a scramble to reconnect people before Jocelyn struck.
As of Tuesday morning, around 4,900 people in the UK were still without power, mainly in northern England and southern Scotland, according to the Energy Network Association. Around 7,000 customers were left without power in Northern Ireland.
The stormy weather has also caused water levels to rise in rivers and lakes across the UK. In England, the Environment Agency issued 13 flood warnings on Tuesday, indicating flooding is expected and immediate action is needed. These include the River Lambourn in Berkshire, Derwent Water in the Lake District and the River Ouse in York.
Flood warnings were also issued for 82 locations in England, telling people to “be prepared” for possible flooding.
There were 15 flood warnings and 10 flood warnings in place in Scotland.
Yellow and yellow weather warnings for wind have been issued for much of the UK, and yellow warnings for rain have been issued for western and southern Scotland and parts of north-west England. A yellow ice warning has been issued across northern and eastern Scotland.
The Bureau of Meteorology said wind gusts of up to 130 miles per hour were possible in exposed areas and 40 to 50 millimeters of rain could fall on higher ground.
Its chief meteorologist Steve Willington said Jocelyn, named by Alienmet Alien after astrophysicist Dame Jocelyn Bell Burnell, could cause further confusion.
“While this system is a step down compared to Storm Isha, we could potentially see further impacts from Storm Jocelyn as damage and cleanup is still ongoing,” Willington said. . “Heavy rain on Tuesday could bring 15-20mm of rain over very wide areas, with 40-50mm of rain expected in the highlands in south-west Scotland, the Scottish Highlands and parts of north-west England. may occur.
“Wind gusts are expected to reach 55-65mph across north-west Scotland, although some locations, particularly exposed parts of the Western Isles and the north-west coast of Scotland, are expected to see winds of 75-65mph in the early stages. could reach 80 mph” Wednesday morning. ”
“Strong winds and heavy rain are likely to cause major disruption to services in Scotland and abroad,” Transpennine Express said.
Catherine O'Brien, director of customer experience and operations at the company, said: “Our top priority is to keep our customers and colleagues safe and we are doing everything we can to keep people moving, even in difficult circumstances. I intend to do it.” We urge people traveling on affected routes to plan ahead, allow plenty of time, check their itineraries at the last minute and follow the guidance provided. ”
Isha has caused at least two deaths in the UK. An 84-year-old man has died after the car he was riding in collided with a fallen tree in Grangemouth, Falkirk.
A man in his 60s died in a crash involving two vans and a fallen tree in Limavady, County Londonderry, on Sunday night.
A 26-year-old man is in a critical condition after his car collided with a tree on a road in Cramlington, Northumberland, police said.
In Bradford, a man reportedly died Monday. Fell into a hole used for road construction maintenance. One of the investigations is that strong winds blew the barrier away.
