Study Suggests Creatine May Have Cancer-Fighting Potential

Creatine, commonly known for enhancing athletic performance, might also play a role in combating cancer, according to recent research.

This affordable supplement not only improves sports performance but also appears to activate a specific type of immune cells that are crucial for fighting cancer, as reported by scientists from the University of California, Los Angeles (UCLA).

Earlier studies on mice indicated that creatine boosts the activity of killer T-cells, which are vital in destroying cancer cells and fighting off viruses. The latest findings reveal that it also energizes dendritic cells, which capture pieces of tumors and signal killer T-cells to engage.

While most immunotherapies target killer T-cells, the response rate among patients isn’t very high. Researchers think that creatine could enhance cancer treatment through its effects on dendritic cells.

Lili Yang, the lead researcher and a professor at UCLA, explained, “Immunotherapy shows great potential, but it works for only some patients. This study indicates that creatine supports not just the T-cells but also the entire framework that aids them. This makes it a potentially valuable supplement for strengthening the immune response that contemporary immunotherapies rely on.”

The study, published in the journal iScience, examined the effects of daily creatine injections in mouse melanoma models to see if they would slow tumor growth.

Results showed a reduction in growth and increased activity of dendritic cells within the tumors. These enhanced dendritic cells released more chemical signals, attracting additional immune cells to the site.

Furthermore, creatine supplementation appeared to elevate energy levels in dendritic cells. Researchers likened creatine’s role to that of a rechargeable battery, enabling these cells to store and release energy as needed, even when up against rapidly dividing tumor cells.

James Elsten-Brown, a co-author and graduate student in Yang’s lab, commented, “The promising aspect of this study is that creatine could serve two functions: enhancing the immune response in patients receiving immunotherapy and improving the quality of dendritic cell vaccines before their administration.”

While the findings point to creatine’s potential in boosting the immune system’s ability to combat cancer, it’s essential to note that this research was conducted on cells and mice. Therefore, it’s premature to make dietary or medical suggestions based on these results.

Despite being a widely used and generally safe supplement, patients undergoing cancer treatment should consult their healthcare provider before adding creatine to their regimen, researchers advise.