Women who are breast cancer survivors living in the poorest areas have a 35% higher risk of developing an unrelated second cancer compared to women in the wealthiest areas. the study is shown.
Breast cancer is the most commonly diagnosed cancer in the UK, with approximately 56,000 people diagnosed with the disease each year. With improved diagnosis and treatment, The 5-year survival rate is currently 86% British.
People who survive breast cancer are more likely to develop a second primary (unrelated) cancer, but the exact risk has not been known until now.
A research team led by the University of Cambridge analyzed NHS data from around 600,000 patients in the UK and found that compared to the general female population, women who survive breast cancer are at greater risk of developing 12 other primary cancers. I found it to be expensive.
They have twice the risk of developing cancer in the unaffected (contralateral) breast, 87% higher risk of endometrial cancer, 58% higher chance of myeloid leukemia, and ovarian cancer. 25% higher risk.
The study, published in Lancet Regional Health – Europe, found that people living in areas with higher levels of socio-economic deprivation were at increased risk of second primary cancers.
Compared to the wealthiest and least wealthy female breast cancer survivors, they had a 166% higher chance of developing lung cancer, a 78% higher risk of stomach cancer, a more than 50% increased risk of bladder and esophageal cancer, and 48 % was high. She has a higher risk of head and neck cancer, and her risk of kidney cancer increases by 43%.
Overall, those from the most disadvantaged regions had a 35% higher risk of second cancers other than breast cancer.
This may be because risk factors such as smoking, obesity, and alcohol consumption are more common in poorer groups. A 2023 study found that poverty causes 33,000 additional cancer cases in the UK each year.
Lead author Isaac Allen, from the University of Cambridge’s School of Public Health and Primary Care, said: “This is the largest study ever to examine second cancers after breast cancer, with women first diagnosed with breast cancer in 2018. This is the first study to show that People in poorer areas are more likely to develop secondary cancers. Many cancers are caused by poverty, but more research is clearly needed to identify the specific factors that cause higher risks and how best to reduce these inequalities. ”
The authors used data from more than 580,000 women, as well as national cancer registry datasets, to identify second primary cancers in more than 3,500 male breast cancer survivors diagnosed between 1995 and 2019. I looked into the risks.
Male breast cancer survivors are 55 times more likely to develop contralateral breast cancer than the general male population, 58% more likely to develop prostate cancer than the general male population, and four times more likely to develop thyroid cancer than the general male population. However, the actual number of these cancers was low.
In response to the findings, leading oncologists, Catch up with cancer campaign“This highlights yet another example of alarming inequalities in cancer, and highlights the urgent need for cancer-specific programs.” should not determine the likelihood of onset or survival. ”
Dr Simon Vincent, Director of Research, Advocacy and Impact at Breast Cancer Now, said that while an increased risk of second cancers can occur due to genetic factors or the effects of early breast cancer treatment, He said further research is needed into the causes of cancer. How to follow up with patients who have completed primary treatment for cancer and breast cancer.
