Pitt season 2 finale: HBO series showcases the doctor’s battle with addiction
Alcohol Use in America: Trends and Challenges Alcohol consumption in the U.S. is at its lowest point in history, which is certainly a positive development for public health. A recent CDC study from 2024 indicated that alcohol is responsible for over 175,000 deaths each year, so any drop in usage is definitely something to celebrate. […]
Alzheimer’s medications targeting amyloid do not demonstrate significant clinical impact
New Review Questions Effectiveness of Alzheimer’s Drugs A recent Cochrane review has raised concerns about drugs targeting amyloid beta proteins in the brain, suggesting they likely have no significant positive effects while also increasing the risk of bleeding and swelling. In individuals with Alzheimer’s disease, levels of amyloid beta—a protein that can be detected before […]
Surprising Source of Salt Could Be Increasing Blood Pressure for Many
When people think about high blood pressure, they usually point to lifestyle choices like salt intake, exercise habits, or smoking. But an unexpected factor might be contributing to hypertension for many individuals: their drinking water. As climate change progresses, salty seawater is seeping into freshwater supplies. This led me, as a public health researcher, to […]
New side effect of cannabis use found in significant study
Hazy memories often come with smoking cannabis, but a recent study indicates something even more intriguing: cannabis might make those memories seem real, even when they’re not. It’s worth noting that despite being illegal as a Class B drug in the UK, cannabis has consistently been the most common illicit substance used in England and […]
Future assessment of genomics-based off-label treatment
Insights into the Drug Rediscovery Protocol (DRUP) Over the last nine years, the Drug Rediscovery Protocol (DRUP) has given hope to more than 1,600 patients suffering from advanced cancers that had no standard treatment options left. Notably, around 39.1% of these patients had rare cancers, which typically offer very few histological treatment choices. They appeared […]
Overall blood volume in the brain shows contrasting groups of neurons
Brainwide fUSI Measurements Research involving five C57/BL6 mice (three males, two females) aged between 13 to 34 weeks was conducted. All procedures adhered to the UK Animals Scientific Procedures Act (1986) and were performed at University College London, sanctioned by a project license from the Home Office post ethical review. Surgery The mice underwent surgical […]
Molecular foundation for methylation-sensitive editing by Cas9
Cloning, protein expression and purification The DNA for ThermoCas9, featuring a C-terminal His6 tag, was integrated into the pML-1B vector and expressed in the Escherichia coli NiCo21(DE3) strain. This involved growing the cells in Luria–Bertani (LB) medium enriched with 0.2% d-(+)-glucose at 37 °C until they reached an optical density of 0.8 at 600 nm. At this […]
A detailed map of the healthy human liver from living donors
Experimental methods Human sample preparation Human samples and clinical data were collected from patients who underwent either hepatectomy for liver conditions or donor hepatectomy for living liver donation. In surgeries related to liver pathologies, samples were taken at least 5 cm away from the pathological margin. For donor surgeries, liver biopsies of 1 cm³ were […]
Oncofetal plasticity is widespread in early colorectal cancers.
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Diet Soda Consumption: What Is an Excessive Amount?
This week, we learned that former President Donald Trump reportedly believes that Diet Coke is beneficial for his health because it can kill grass, suggesting it might also be effective against cancer cells. Dr. Mehmet Oz, who was involved with Medicare and Medicaid under Trump, simply stated, “I’m not even going to argue this right […]